Disclaimer: This is not medical advice, consult with your doctor before taking a new prescription or supplement.
What is microvascular disease
Small vessel disease is a condition in which the walls of the small arteries in the heart aren't working properly. This reduces the flow of oxygen-rich blood to the heart, causing chest pain (angina), shortness of breath, and other signs and symptoms of heart disease. Small vessel disease may also be called Microvascular endothelial dysfunction.
Coronary small vessel disease is a condition in which the walls of the small arteries in your heart — the tiny branches off the larger coronary arteries — are damaged and don’t dilate properly.
Your small vessels need to expand to provide oxygen-rich blood to your heart. When they’re damaged, the blood flow to your heart decreases. This can cause serious problems in your heart that can lead to problems in other parts of the body.
It’s also called coronary microvascular disease and small artery disease.
First read this post below. This is information on microvascular disease and the mechanism. Followed later by treatments in my post below.
Then continue on to these comments about treatments.
Your treatment list includes some Nrf2 promoters. That is what I have found helpful and recommend. When anything inflammatory is promoting NfKB, then at the same time Nrf2 is being inhibited. The share a circadian protein so cannot both be active at the same time.
Fight back with Nrf2 promoters. Sulforaphane, resveratrol, EPA/DHA, curcumin, citrus or pomegranate peel, quercetin, genistein, others.
Which is also covered in this post.
Then in this comment with some studies:
I have ALL people who took them alive/surviving so called Covid, including hospitalized patients in very bad condition. And I have growing number of heavy injured people to getting back on track and feeling well, but due to toxicity of those shots they must be taking antioxidants constantly.
NAC, Ivermectin- if available, Zinc, Quercetin, Vitamin C - and others: Q10, K2MK7, Vit E, Resveratrol, Vit D, Vit B, Beta Carotene, Nigella Sativa, Turmeric, etc. - they are all antioxidants and stop apoptosis of the cell.
Why Glutathione - If I would really have no money and access to anything else, I would go for N-acetylcystaine - NAC and I would add other antioxidants that available.
NAC dissolves blood clots, but also amyloid plaque. It is Glutathione precursor and glutathione is THE MASTER of all antioxidants. Basically, all other will work when Glutathione is in place.
https://madsa.org.my/how-nac-should-be-part-of-stroke-prevention-diet/ - The study by CHOP researchers suggests NAC may block the precipitation of amyloid plaque deposits, as well as help break up their formation, which could make a dramatic difference for those living with HCCAA. The study’s lead author, Dr. Hakon Hakonarson, director of CHOP’s Center for Applied Genomics, said in a news release:10
“Amyloids cannot precipitate without aggregating, so if we can prevent that aggregation with a drug [NAC] that is already available, then we could make an incredible difference in the lives of these patients.
NAC broke the oligomers into monomers (oligomers are composed of a few monomer units13), which helps prevent the formation of amyloid deposits linked to strokes.14 “Given the results from the described cellular work, it became evident that NAC could potentially be useful to treat this devastating disease,” the researchers wrote in Nature Communications.15
https://www.hindawi.com/journals/neuroscience/2019/7547382/ - It can be postulated that NAC might have reversed the effect of intraneuronal beta amyloid protein by acting on some downstream compensatory mechanisms which needs to be explored.
The antioxidant NAC has reversed the cognitive deficits and inhibited microglia activation but failed to inhibit expression of BAP positive neurons and reactive astrocytes in an animal model of AD. It can be postulated that NAC might have reversed the effect of intraneuronal beta amyloid protein by acting on some downstream compensatory mechanism which needs to be explored.
https://pubmed.ncbi.nlm.nih.gov/30641367/ How graphene affects the misfolding of human prion protein: A combined experimental and molecular dynamics simulation study
Sources for treatment
NAC, N-acetyl-cysteine, can be hard to find on Amazon.com. Try Ebay or another site instead.
Edit: There is some evidence that NAC supports tumor formation and growth
Use at your own risk.
Problems with n-acetyl-cysteine, NAC, causing tumors. In mice with activating mutations in K-Ras or B-Raf, which are commonly seen in human lung cancers, antioxidants (NAC and vitamin E) actually seem to accelerate the growth of the tumors. That was reported in 2014, and you won't hear much about it down at the drug store. Now there's a study looking at not just growth of existing tumors, but tumor initiation itself, and the news is disturbingly similar. But it's even more important to realize that (up to a point) NAC supplementation looks like it's doing a lot of good. (Good article with many links.) https://www.science.org/content/blog-post/n-acetyl-cysteine-warning-shot
Possible Beneficial Effects of N-Acetylcysteine for Treatment of Triple-Negative Breast Cancer. Youngjoo Kwon. National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/33498875/ *However, the cancer-promoting effect of NAC* observed in some preclinical studies has raised concerns regarding its clinical use. Reactive oxygen species (ROS) can mediate signaling that results in both cancer-promoting and cancer-suppressing effects. The beneficial effect of NAC may depend on whether the type of cancer relies on ROS signaling for its survival and metastasis. Cite: Kwon Y. Possible Beneficial Effects of N-Acetylcysteine for Treatment of Triple-Negative Breast Cancer. Antioxidants (Basel). 2021 Jan 24;10(2):169. doi: 10.3390/antiox10020169. PMID: 33498875; PMCID: PMC7911701.
In those studies showing NAC feeding tumors, when you convert the dosing of the mice to Human equivalents the NAC doses are HUGE.
This is good research, that will help save lives! Thank you.